What is Ranozex 500mg ?
Ranozex 500mg (Ranolazine Extended Release Tablets) is a medicine used for angina (heart-related chest pain) treatment. It helps to prevent new angina attacks in a chest portion, but Ranozex 500mg medication does not help to stop an acute attack, once it has started. Ranozex pain medication relieves chest pain by making the heart work more efficiently
It is via the oral route that a pharmacist prescribes this drug. This drug proves successful against serious medical conditions such as chronic angina. It shows its efficacy in the treatment of atrial fibrillation.
The function of this medication needs to be clearly understood. It does have a close association with the use of adenosine triphosphate. Ranolazine od 500mg also functions by consistently preventing the movement of sodium within the heart muscle. It is very useful to treat an irregular heartbeat, mainly in combination with other drugs.
In 1985, Syntex Inc first began developing Ranozex 500. However, the drug’s approval for clinical use was made official in the United States of America in 2006. It was in 2019 that this medication was the most prescribed drug in the US.
How does Ranozex 500mg ER Tablet Work?
It is via the continuous inhibition of the sodium movement in the voltage-gated sodium channels in the heart muscles. This type of inhibition helps reduce intracellular sodium levels, which triggers a decrease in tension in the heart wall. The requirement for oxygen also decreases.
Ranozex 500mg does have the capacity to affect delayed rectifier current usually available within the potassium channels. Therefore, it only means that this medication can extend the action’s potential duration. It does this by extending the QT interval on the electro-cardio cardiography. It is the suppression of the lKr that lengthens its ventricular action potential, which is why there is Ranozex 500, which exerts the 500 mg QT prolonged effect on the surface of the electrocardiogram.
The metabolism of Ranozex 500mg involves the presence of CYP3A and also CYP2D6. The solution form of this medicine is eliminated via urine or feces.
Chemical Structure of Ranozex 500mg:
This medicine is structurally known as 1-piperazineacetamide, N-(2,6-dimethyl phenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl].
Ranozex 500mg in appearance is solid in form and white to off-white. It is not very soluble in water but in ethanol, acetonitrile, tetrahydrofuran, dichloromethane, methanol, and acetone. Finally, Ranozex 500 mg is soluble in organic compounds such as ethyl ether, ethyl acetate, toluene, and isopropanol.
Drug Interactions of Ranozex 500mg Tablets:
It is not advisable to consume Ranozex 500mg along with other drugs since there is the possibility of adverse interaction occurring. Hence, if you are currently using some of the medications mentioned in the list below:
- St John’s Wort
- Seizure medication that includes phenytoin, Phenobarbital, and carbamazepine
- Antifungal medicines like ketoconazole and itraconazole
- HIV/AIDS medication
What are The Dosage Guidelines of Ranozex 500mg Tablets?
It depends on the type of tissue that the dosage plan of Ranozex 500mg is set.
They are as follows:
For angina chest pain in adults:
The recommended start dose is 500mg mg orally twice daily. If necessary, your doctor will increase the dose from 1000 mg twice daily.
In case of overdosing on Ranozex 500, what is to be done?
There is a distinct possibility that you may overdose on Ranozex 500. If so, you may experience tingling, vomiting, numbness, nausea, and fainting symptoms. You need to ensure that you seek out immediate medical attention by calling your doctor on an immediate basis.
What are The Side Effects of Ranozex 500mg ER Tablets?
Like, most allopathic medicines, Ranozex 500mg has several side effects. They are as follows:
- Nauseous feeling
- Face, throat, or even tongue swelling
Apart from side effects, there are also some adverse effects that Ranozex 500mg can trigger. They include:
- Feeling of fatigue
- Pain while urinating
- Edema in ankle or foot
- Shortness of breath
- Headache along with severe dizziness, pounding heartbeats, and chest pain
- Lightheaded feeling
Firstly, if you are suffering from liver cirrhosis, you must avoid taking Ranozex 500mg immediately. Secondly, if you have diabetes, you need not worry because, as per the pharmacokinetics of this drug, diabetes has no impact whatsoever. Thirdly, the pharmacokinetic data analysis undertaken on angina patients suggests that people with diabetes need to change their dose.
It will also be beneficial if you keep in mind that drug interactions may occur when some medications are used along with this drug. Hence, you must inform your healthcare professional with every detail of the medications you are currently consuming or any that you have stopped taking.
If you are experiencing serious chest discomfort, you should stop taking Ranozex 500. However, before taking this medication, you must inform your doctor about your medical history, specifically if you have had a family or personal history of Long QT syndrome.
Finally, you need to understand that doctors use drugs in combinations to treat chronic angina. Therefore, you need to use all medications as prescribed by your physician. It is also necessary that you consult your doctor before altering the dosage of Ranozex 500.
How to Take Ranozex 500mg Tablet?
To begin with, you must take Ranozex 500mg under the guidance and instructions of your physician. It would also be beneficial if you followed the prescription on the drug label to get maximum results. You must know that using Ranozex 500 mg well outside a specific range for a long duration is possible.
You can take this medication either with or without food. It is simply because consumption of this drug has no impact on AUC and Cmax. Therefore, you can take this drug with or without taking your meals. Regarding an extended-release tablet of Ranozex 500, you must avoid trying to break, chew, or crush it and only inhale it.
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What do You Need to Avoid While Consuming Ranozex 500mg Tablet?
Ranozex 500mg is a drug that makes you behave very differently. Therefore, you need to keep this in mind before consuming it.
If you take this drug, you must avoid driving or performing any activity that needs alertness.
You must remember that Ranozex 500 mg can interact with grapefruit and juice. Hence you need your doctor to understand the usage instructions of Ranozex 500.
Brand Names of Ranozex 500mg?
One popular brand name of the Ranozex 500mg is Ranexa.
Frequently Asked Questions:
Q. How does Ranozex 500mg exert its effect on the heart?
Ranozex 500mg helps reduce the flow of calcium into the heart’s cells, thereby helping it relax, relieving symptoms of angina pectoris, and thereby improving blood flow to the heart muscle.
Q. When do you need to stop taking Ranozex 500?
This medication you should not use to treat abrupt onset chest discomfort. If you notice any changes in your heart rhythm, call your doctor immediately. Your heartbeat could be quick, hammering, or irregular, and you might feel lightheaded or faint. If you ever experience a heart rhythm issue, such as QT prolongation, be sure to let your physician aware of it.
Q. Can Ranozex 500mg make you feel sleepy?
On consumption of Ranozex 500, you may feel light in the head, less alert, or sometimes even drowsy.
Q. Is blurred vision one of the side effects of taking Ranozex 500?
Yes, on taking Ranozex 500, there is a chance that you may experience blurred vision along with other symptoms such as dizziness. Therefore, it may affect your ability not only to drive and even to operate the machine.
Q. Does Ranozex 500mg help in treating shortness of breath?
The subject’s capacity to exercise and shortness of breath may be helped by Ranozex 500. This drug has only been FDA-approved for the treatment of persistent angina.
Q. Is it possible to use Ranozex 500mg and metoprolol together?
Ranozex 500, when taken with metoprolol, may stimulate the increase of blood levels. Therefore, you may need dose adjustments and regular monitoring by your doctor to take these medications together safely. You must contact your doctor if you experience increased side effects or if your medical condition changes.
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