What is Ranolazine 500 mg ?
Ranolazine 500 mg is a medicine used for angina (heart-related chest pain) treatment. It helps to prevent new angina attacks in a chest portion, but Ranolazine 500 mg medication does not help to stop an acute attack, once it has started. Ranolazine pain medication relieves chest pain by making the heart work more efficiently. Ranolazine 500mg Extended Release (ER) Tablet is an anti-anginal medicine used alone or with other medicines to treat heart related chest pain (chronic angina).
It is via the oral route that a pharmacist prescribes this drug. This drug also proves successful against serious medical conditions such as chronic angina. Additionally, it also shows its efficacy in the treatment of atrial fibrillation.
The function of this medication needs to be clearly understood. It does have a close association with the use of adenosine triphosphate. Ranolazine od 500 mg also functions by consistently preventing the movement of sodium within the heart muscle. It is very useful to treat an irregular heartbeat, mainly in combination with other drugs.
How does Ranolazine 500 mg Tablet Work?
Ranolazine 500 mg works by constantly inhibiting the current sodium movement in voltage-gated sodium channels within the heart muscle. This current inhibition reduces intracellular calcium levels, thereby triggering a significant decrease in tension in the heart wall. Te need for oxygen also decreases.
Ranolazine 500mg affects the delayed rectifier current seen within the potassium channels. Above all, this drug helps extend the action potential duration by prolonging the QT interval on electrocardiography. The suppression of IKr, which lengthens the ventricular action potential, is the cause of the Ranolazine 500mg exhibiting the QT-prolonging effect on the surface electrocardiogram.
Ranolazine 500mg is primarily metabolized by CYP3A, with little contribution from CYP2D6. Its solution is eliminated in the urine and feces roughly equal amounts after a single oral dose—around 75% and 25%, respectively. Less than 5% of the drug is eliminated intact in the urine and faeces; it is processed swiftly and extensively in the liver and intestine. The metabolites’ pharmacologic activity has not been thoroughly studied.
Chemical Structure and Composition of Ranolazine 500 mg Tablets:
Ranolazine, also known as 1-piperazineacetamide, N-(2,6-dimethyl phenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl], is a racemic combination.
The solid form of Ranolazine is white to off-white. In addition to being barely soluble in water, this drug is soluble in dichloromethane, methanol, tetrahydrofuran, ethanol, acetonitrile, and acetone. It is also mildly soluble in ethyl acetate, isopropanol, toluene, and ethyl ether.
What are The Drugs That Interact with Ranolazine 500 mg?
Consuming a few medications along with Ranolazine 500 mg is not advisable due to potential interactions. Therefore, if you happen to use any of the medicines listed below, your doctor may need to modify your treatment strategy:
- Antifungal medicines like itraconazole, ketoconazole etc
- Seizure medicine includes carbamazepine, phenobarbital, and phenytoin.
- St. John’s Wort
- Tuberculosis medicine, for example, rifabutin, rifampin, rifapentine
- HIV or AIDS medicine
What are The Uses of Ranolazine 500 mg Tablets ?
Ranolazine 500 mg is used to treat chronic angina attacks. It helps to enhance the blood flow to perform the heart more efficiently. It would help if you remembered that when experiencing an acute angina attack, you need to take Ranolazine 500. This medicine is also put to use in treating cardiac rhythm problems.
What are The Dosage Guidelines of Ranolazine 500 mg Tablets?
The dosage plan for Ranolazine 500mg depends upon the type of heart issue. It is given below:
Ranolazine 500 mg dosage schedule for angina (chest pain) in adults:
You must take 500 mg orally twice daily as the usual starting dose. Your doctor may increase the dosage to 1000 mg twice daily if necessary.
What happens if you overdose on Ranolazine 500 mg?
Overdosing on Ranolazine 500 mg may trigger symptoms like vomiting, tingling or numbness, double vision, confusion, fainting, or nausea. You need to seek immediate medical attention by contacting your doctor if you overdose on this drug.
What are The Side Effects of Ranolazine 500 mg Tablets?
You may experience several side effects when taking Ranolazine 500 mg. A few of them include
- Unable to breathe
- Swelling on the face, tongue, or throat
Ranolazine 500mg can also trigger a few side effects. If you experience any of the following symptoms given below, call your doctor immediately.
- Painful urination
- Ankle or foot edema
- Shortness of breath
- Headache followed by severe dizziness, pounding heartbeats, and chest pain
- A sense of lightheadedness
Precautions Needed While Taking Ranolazine 500 mg Tablet
If you have liver cirrhosis, you need to avoid Ranolazine 500 mg. Compared to individuals without hepatic impairment, the Cmax of Ranolazine was elevated by 80% in cirrhotic patients with moderate (Child-Pugh Class B) hepatic impairment as opposed to mild (Child-Pugh Class A) cirrhotic patients. The three-fold increase in QT prolongation seen in cirrhotic patients with mild to moderate hepatic impairment could not be explained by this increase alone.
Diabetes had no impact on the pharmacokinetics of Ranolazine, according to a population pharmacokinetic analysis of data from angina patients and healthy volunteers. People living with diabetes don’t need to change their dose. The clinical relevance of Ranolazine 500mg’s modest HbA1c decreases in diabetic patients is uncertain.
It would help if you also kept in mind that serious drug interactions may happen when some medications are used with this medicine. Therefore, you need to inform all of your healthcare professionals about any medication you are currently taking and any that you begin or stop using.
When you are experiencing an acute bout of chest discomfort, it is advisable not be take Ranolazine 500mg. If you intend to treat severe chest discomfort, continue taking any additional medications your doctor gave, such as nitroglycerin.
You must inform your doctor about your health issues before taking Ranolazine 500mg, especially if you have a personal or family history of Long QT syndrome.
Also, drug combinations are frequently used to treat chronic angina. Use all of your medications as prescribed by your doctor for the best results in treating your disease. Without consulting your doctor, never alter your dosage or routine for taking your medications.
The brand names of Ranolazine 500 mg:
A few popular brand names of Ranolazine 500mg is Ranexa.
How to Take Ranolazine 500 mg?
You must take Ranolazine 500 mg precisely as directed by your physician. It would help if you observed every instruction on the prescription drug label to ensure that you get optimum results. Your doctor may occasionally adjust your dose. Using this medication outside of the specified range or for a longer duration is not advisable.
You can take Ranolazine 500mg either with or without food. It is mainly because food consumption has no significant impact on this drug’s Cmax and AUC. As a result, you can take this medication regardless of whether you have your meal or not. An extended-release tablet should not be chewed, crushed, or broken; you must completely inhale it.
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Things You Need to Avoid While Taking Ranolazine 500 mg:
Before consuming Ranolazine 500 mg, you must understand that it makes you think or act differently. Using caution is also essential to avoid driving or doing anything else that calls for alertness.
Ranolazine 500mg may also interact with grapefruit and juice, causing undesirable side effects. With your doctor, go through grapefruit product usage.
Frequently Asked Questions:
Q. What does Ranolazine 500 mg do for the heart?
Ranolazine 500 mg is supposed to assist the heart in relaxing by lowering the influx of calcium into the cells, improving blood flow to the heart muscle, and easing angina pectoris symptoms.
Q. Is it true that Ranolazine 500 mg causes weight gain?
Ranolazine 500 mg’s common side effect is not weight gain. However, it can cause edema (excess fluid) in the arms and legs; thus, you could perhaps gain weight from the extra water weight.
Q. Does consuming Ranolazine 500 mg give you energy?
Energy use increases while taking this drug. Ranolazine 500 mg increases energy expenditure, as determined by indirect calorimetry examined 3 weeks after therapy when whole-body O2 consumption rates normalized to lean body mass were significantly higher.
Q. Is it possible that Ranolazine 500mg affects blood pressure?
The well-tolerated medicine ranolazine, a piperazine derivative offered under Ranexa, explicitly blocks the late sodium current. Ranolazine does not impact heart rate or blood pressure and has advantageous metabolic qualities.
Q. What is the impact of Ranolazine 500 mg on kidney function?
Ranolazine’s inhibition of creatinine tubular secretion is unaffected by the glomerular filtration rate. Acute renal failure, however, has been documented in patients with marked severe impairment (creatinine clearance [CrCl] fewer than 30 ml per minute).
Q. Is it true that Ranolazine 500 mg lowers the heart rate?
Anti-ischaemic drug ranolazine does not lower blood pressure or heart rate. It is licensed as adjunctive therapy to standard treatments for people with stable angina pectoris who have not responded to standard medications.