What is Ranolaz OD 500mg ?
Ranolaz OD 500mg (Ranolazine Extended Release Tablets) is a medicine used for angina (heart-related chest pain) treatment. It helps to prevent new angina attacks in a chest portion, but Ranolaz OD 500mg medication does not help to stop an acute attack, once it has started. Ranolaz OD pain medication relieves chest pain by making the heart work more efficiently
It is via the oral route that a pharmacist prescribes this drug. This drug also proves successful against serious medical conditions such as chronic angina. Additionally, it also shows its efficacy in the treatment of atrial fibrillation.
The function of this medication needs to be clearly understood. It does have a close association with the use of adenosine triphosphate. Ranolazine od 500mg also functions by consistently preventing the movement of sodium within the heart muscle. It is very useful to treat an irregular heartbeat, mainly in combination with other drugs.
In 1985, Syntex Inc first began developing Ranolaz od 500 mg. However, the drug’s approval for clinical use was made official in the United States of America in 2006. It was in 2019 that this medication was the most prescribed drug in the US.
How does Ranolaz OD 500mg ER Tablet Work?
It is via the continuous inhibition of the sodium movement in the voltage-gated sodium channels in the heart muscles. This type of inhibition helps reduce intracellular sodium levels, which triggers a decrease in tension in the heart wall. Besides, the requirement for oxygen also decreases.
Ranolaz od 500mg does have the capacity to affect delayed rectifier current usually available within the potassium channels. Therefore, it only means that this medication can extend the action’s potential duration. It does this by extending the QT interval on the electro-cardio cardiography. In addition, it is the suppression of the lKr that lengthens its ventricular action potential, which is why there is Ranolaz od 500 mg, which exerts the 500 mg QT prolonged effect on the surface of the electrocardiogram.
The metabolism of Ranolaz od 500 mg involves the presence of CYP3A and also CYP2D6. The solution form of this medicine is eliminated via urine or feces.
Chemical Structure of Ranolaz od 500mg:
This medicine is structurally known as 1-piperazineacetamide, N-(2,6-dimethyl phenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl].
Also, Ranolaz od 500mg in appearance is solid in form and white to off-white. It is also not very soluble in water but in ethanol, acetonitrile, tetrahydrofuran, dichloromethane, methanol, and acetone. Finally, Ranolaz od 500 mg is soluble in organic compounds such as ethyl ether, ethyl acetate, toluene, and isopropanol.
Drug Interactions of Ranolaz OD 500mg Tablets:
It is not advisable to consume Ranolaz od 500mg along with other drugs since there is the possibility of adverse interaction occurring. Hence, if you are currently using some of the medications mentioned in the list below:
- St John’s Wort
- Seizure medication that includes phenytoin, Phenobarbital, and carbamazepine
- Antifungal medicines like ketoconazole and itraconazole
- HIV/AIDS medication
What are The Dosage Guidelines of Ranolaz OD 500mg Tablets?
It depends on the type of tissue that the dosage plan of Ranolaz od 500mg is set.
They are as follows:
For angina chest pain in adults:
The recommended start dose is 500 mg orally twice daily. Besides, if necessary, your doctor will increase the dose from 1000 mg twice daily.
In case of overdosing on Ranolaz od 500 mg, what is to be done?
There is a distinct possibility that you may overdose on Ranolaz od 500 mg. If so, you may experience tingling, vomiting, numbness, nausea, and fainting symptoms. More importantly, you need to ensure that you seek out immediate medical attention by calling your doctor on an immediate basis.
What are The Side Effects of Ranolaz od 500mg ER Tablets?
Like, most allopathic medicines, Ranolaz od 500mg has several side effects. They are as follows:
- Nauseous feeling
- Face, throat, or even tongue swelling
Apart from side effects, there are also some adverse effects that Ranolaz od 500 mg can trigger. They include:
- Feeling of fatigue
- Pain while urinating
- Edema in ankle or foot
- Shortness of breath
- Headache along with severe dizziness, pounding heartbeats, and chest pain
- Lightheaded feeling
Firstly, if you are suffering from liver cirrhosis, you must avoid taking Ranolaz od 500mg immediately. Secondly, if you have diabetes, you need not worry because, as per the pharmacokinetics of this drug, diabetes has no impact whatsoever. Thirdly, the pharmacokinetic data analysis undertaken on angina patients suggests that people with diabetes need to change their dose.
Furthermore, it will also be beneficial if you keep in mind that drug interactions may occur when some medications are used along with this drug. Hence, you must inform your healthcare professional with every detail of the medications you are currently consuming or any that you have stopped taking.
If you are experiencing serious chest discomfort, you should stop taking Ranolaz od 500mg. However, before taking this medication, you must inform your doctor about your medical history, specifically if you have had a family or personal history of Long QT syndrome.
Finally, you need to understand that doctors use drugs in combinations to treat chronic angina. Therefore, you need to use all medications as prescribed by your physician. It is also necessary that you consult your doctor before altering the dosage of Ranolaz od 500mg.
How to Take Ranolaz OD 500mg Tablet?
To begin with, you must take Ranolaz od 500mg under the guidance and instructions of your physician. In addition, it would also be beneficial if you followed the prescription on the drug label to get maximum results. Also, you must know that using Ranolaz od 500 mg well outside a specific range for a long duration is possible.
Furthermore, you can take this medication either with or without food. It is simply because consumption of this drug has no impact on AUC and Cmax. Therefore, you can take this drug with or without taking your meals. Regarding an extended-release tablet of Ranolaz od 500, you must avoid trying to break, chew, or crush it and only inhale it.
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What do You Need to Avoid While Consuming Ranolaz OD 500mg Tablet?
Ranolazine od 500mg is a drug that makes you behave very differently. Therefore, you need to keep this in mind before consuming it.
If you take this drug, you must avoid driving or performing any activity that needs alertness.
In addition, you must remember that Ranolaz od 500 mg can interact with grapefruit and juice. Hence you need your doctor to understand the usage instructions of Ranolaz od 500.
Brand Names of Ranolaz OD 500 mg?
One popular brand name of the Ranolaz od 500 mg is Ranexa.
Frequently Asked Questions:
Q. How does Ranolaz od 500mg exert its effect on the heart?
Ranolazine od 500mg helps reduce the flow of calcium into the heart’s cells, thereby helping it relax, relieving symptoms of angina pectoris, and thereby improving blood flow to the heart muscle.
Q. When do you need to stop taking Ranolaz od 500mg?
This medication you should not use to treat abrupt onset chest discomfort. Furthermore, if you notice any changes in your heart rhythm, call your doctor immediately. Your heartbeat could be quick, hammering, or irregular, and you might feel lightheaded or faint. If you ever experience a heart rhythm issue, such as QT prolongation, be sure to let your physician aware of it.
Q. Can Ranolaz od 500 mg make you feel sleepy?
On consumption of Ranolaz od 500 mg, you may feel light in the head, less alert, or sometimes even drowsy.
Q. Is blurred vision one of the side effects of taking Ranolaz od 500?
Yes, on taking Ranolaz od 500mg, there is a chance that you may experience blurred vision along with other symptoms such as dizziness. Therefore, it may affect your ability not only to drive and even to operate the machine.
Q. Does Ranolaz od 500mg help in treating shortness of breath?
The subject’s capacity to exercise and shortness of breath may be helped by Ranolaz od 500. This drug has only been FDA-approved for the treatment of persistent angina.
Q. Is it possible to use Ranolaz od 500mg and metoprolol together?
Ranolazine od 500mg, when taken with metoprolol, may stimulate the increase of blood levels. Therefore, you may need dose adjustments and regular monitoring by your doctor to take these medications together safely. You must contact your doctor if you experience increased side effects or if your medical condition changes.