Hydroxychloroquine 200 mg Tablets

What is Hydroxychloroquine 200 ?

Hydroxychloroquine 200 tablet is a 4-Aminoquinoline antimalarial tablet used to treat Maleria (works in the areas where malaria remains sensitive to it’s effect). It works to promote hemoglobin levels. They fall under the category of 4-Aminoquinoline Derivative. As a potent anti-parasitic medicine, it also shows trace effects in slowing down the symptoms of COVID 19 side effects. The availability of Hydroxychloroquine 200 in the oral form is one of the better reasons why doctors recommend having this medicine for their patients. This is because the bioavailability of oral medicines is always higher than syrup or injectable forms.

Hydroxychloroquine 200mg tablets are made of the same drug name Hydroxychloroquine. It manages the post pain of infectious diseases and hence also hails from the family of pain analgesics. In the United States alone, it is an FDA-approved drug since 1955 and is also present in the List of Essential Medicines by WHO. In a Hydroxychloroquine online survey, the evidence provided was that it was the 122nd most commonly prescribed medicine in the States. It also has over 5 million official prescriptions in the States.

IPCA manufactures and supplies Hydroxychloroquine 200 tablets in the United States and other major European countries while also providing the anti-malaria tablets in Australia. As a generic medicine production since 2018, it reached user favorability after it was proven helpful in reducing the COVID 19 symptoms.

What are The Uses of Hydroxychloroquine 200 mg?

Primarily doctors highly prescribe Hydroxychloroquine 200 mg for treating Malaria but it also treats other conditions like:

Rheumatoid Arthritis:

Rheumatoid arthritis (RA) is a joint autoimmune disorder that is a condition where an abnormal immune system starts to attack the healthy parts of the body. Patients experience severe acute pain and stiffness in some parts of the body especially joint regions. They also face swelling and warmth in such regions. This medical condition comes in association with other problems such as osteoporosis, cancer, infection, heart problems, mental ill health, and fatigue syndromes.

Lupus erythematosus:

Another autoimmune disease comes in a variety/of collections that attack healthy tissues of the body. Symptoms of Lupus erythematosus include fatigue, weight loss, headaches, oral ulcer (painless), unusual fever, malaise, rashes on the face, hair loss, photosensitivity, or swollen lymph nodes. Lupus is a collection of diseases that are autoimmune and among the worst form of Lupus is systemic lupus erythematosus.

Q fever:

Q fever is an infection that occurs due to bacteria known as Coxiella burnetii which is tick-borne. It contains signs or symptoms like fever, loss of appetite, muscle pain, joint pain, severe headache, chills, confusion, nausea, and many more. This organism’s presence is very uncommon as it is found in animals and infection occurs if a person comes in contact with things like feces, urine, or semen.

Post-Lyme arthritis

Lyme disease is a medical condition where a person shows a red rash that gradually spreads all over. It happens because of the Borrelia bacterium that enters the human body with the help of its vector which is a tick belonging to the Ixodes genus. The red rash does not make a patient experience any kind of itching or pain, it simply just spreads across the body causing symptoms such as tiredness, headaches, and fevers initially. Later it may turn into joint pain and severe headaches if the conditions remain untreated otherwise.

Although, Hydroxychloroquine 200 mg is given to patients with Sjögren syndrome for treatment it does not prove to be an effective drug for it. Sjögren syndrome.

How does Hydroxychloroquine 200 Tablet Work?

Hydroxychloroquine 200 mg works by increasing antigen-presenting cell lysosomal (membrane-enclosed organelles containing enzymes breaking down biological polymers) pH primarily. We can further understand Hydroxychloroquine 200mg works in the points given below:

• Increase pH within intracellular vacuoles
• Hydrolyses acid in the lysosomes results in the alteration of various processes like protein degradation
• Assembling macromolecules in endosomes
• Proteins present in Golgi bodies go through post translational modification
• Suppresses activation of Toll-like receptors
• Modulates systemic lupus erythematosus
• Kill Malaria causing organism
• Decreases the activity of the immune system
• Interfere proteolyze hemoglobin ability of a parasite
• Reduce inflammatory response

How Long does Hydroxychloroquine 200 mg Last?

Pharmacokinetically, Hydroxychloroquine 200 mg is similar to chloroquine but with slightly different medicinal features. If you are getting your treatment through Hydroxychloroquine 200mg then you need to consume it for a long time. More than 12 weeks or longer might take to show you its sign of effectiveness and it lasts for about 3 months inside the body.

When & How to Take Hydroxychloroquine 200 mg?

Hydroxychloroquine 200 mg is a strong medicine so you need to be thorough and careful in following your doctor’s prescription and instructions carefully. Consume Hydroxychloroquine 200mg only as per your requirement, not too much or too less, and frequently, it can also lead you to side effects that can be extremes. Hydroxychloroquine 200mg comes in oral tablet form that you do not need to break, chew, or crush rather swallow the whole pill with a sufficient drink.

Taking this medicine with meals or after meals is advisable by experts. It further helps you to prevent stomach upset. Even if you start to see the effect of Hydroxychloroquine 200 mg sooner, you should not discontinue it because it’s not clear yet if your infection is resolved or not. Doctors frequently check up on your eyes because this medicine can affect parts of the body, especially the eyes.

Doses of Hydroxychloroquine 200 mg can be in a pattern or the doses can also decrease after some time. It depends on your condition and how much your body can tolerate this medicine because there is a very fine line between Hydroxychloroquine 200mg becoming toxic and therapeutic to the patient’s body. This drug further transfers to breast milk as well, so there is no evidence or study to prove that this medicine cannot harm the baby or pregnant mother. Hence, in cases like Malaria during pregnancy, this medicine is given to them under close doctor’s observation.

What are The Dosage Guideines of Hydroxychloroquine 200 mg Tablets?

The dosing pattern of Hydroxychloroquine 200 mg differs every time depending on your body’s medical condition, weight, age, and also drug tolerance. Dosages of Hydroxychloroquine 200mg are as follows:

Dosage for Arthritis

• Adult- 400/600 mg of Hydroxychloroquine per day initially then 200/400 mg per day
• Children- Doctor determines their dose

Dosage for Malaria

• Prevention

1. Adult- 400 mg of Hydroxychloroquine same time once a week
2. Children of 31 kgs or more- 6.5mg per kg same time once a week. Not more than 400mg

• Treatment

1. Adult- 800 mg of Hydroxychloroquine as an initial single dose then 400 mg at 6, 24, and 48 hours
2. Children of 31 kgs or more- 13 mg per kg of Hydroxychloroquine as an initial single dose then 6.5 mg per kg at 6, 24, and 48 hours. Doses not more than 400 mg

Dosage for lupus

• Adult- 200 mg of Hydroxychloroquine once a day
• Children- Doctor determines their dose

Dosage for Q Fever

• 600 mg of Hydroxychloroquine per day

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Misses Dosage Guidelines of Hydroxychloroquine 200 mg?

As per the explanation given above, you can understand that most of the Hydroxychloroquine 200 mg doses follow a routine of a single dose per day. So, in most cases of missing doses, you can take it any time of day, and if your next dose interval is near then only skip the dose. Withdrawal symptoms of Hydroxychloroquine 200mg may also occur if you miss this medicine in rare cases. So, inform your doctor about this as well.

Overdose Guidelines of Hydroxychloroquine 200 mg?

Overdosing on Hydroxychloroquine 200 mg is very rare because the dose intervals of all medicines are quite afar but the effects of overdosing can prove to be extremely harmful to your health. Hydroxychloroquine 200mg overdosing can be fatal also. You can further understand whether you or someone you know is overdosing on Hydroxychloroquine 200mg then check for the signs like:

• Sleepiness
• Seizures
• Vision
• Coma
• Breathing difficulty
• Ventricular fibrillation
• Low blood potassium
• Permanent loss of vision
• Low blood pressure
• Widening of QRS complex
• QT interval prolongation

Treating rare cases of Hydroxychloroquine 200 mg overdosing include:

• Heart monitoring
• Mechanical ventilation
• Activated charcoal usage
• INtravenous flids and vasopressor’s support
• Use of epinephrine with vasopressor
• Benzodiazepines medicines for seizures
• QRS complex widening resolving with hypertonic saline and sodium bicarbonate
• Stomach pumping
• Intravenous potassium chloride supply

What are The Side Effects of Hydroxychloroquine 200 mg Tablets?

Doses of Hydroxychloroquine 200 mg are given to an individual very carefully and its side effects are very rare to occur. However, there still exist chances of Hydroxychloroquine 200mg side effects occurring in person in a few cases. They are as follows:

• Nausea
• Hallucinations
• Stevens-Johnson syndrome
• Eye problems
• Tretinopathy
• Depression
• Toxic epidermal necrolysis
• Stomach cramps
• Diarrhea
• Systemic symptoms
• Eosinophilia
• Suicidal thoughts
• Agitation
• Mania
• Sleeping problems
• Atypical lymphocytosis
• Psychosis
• Catatonia
• Paranoia
• Serious skin problems
• Heart problems
• Loss of appetite
• Acne
• Impact on Eosinophilia
• Blood abnormalities
• Lymphopenia
• Mouth or eye blister
• Liver failure
• Weakness
• Idiosyncratic hypersensitivity reactions
• Altered eye pigmentation
• Headache
• Low blood sugar
• QT interval prolongation
• Anemia
• Bleaching of hair
• Psoriasis
• Reading difficulty
• Nightmares
• Hair loss
• Muscle paralysis
• Skin scaling
• Weight loss
• Skin rashes
• Urinary incontinence
• Tinnitus
• Skin inflammation
• Vertigo

Who should Avoid Hydroxychloroquine 200 mg?

According to the drug labels of Hydroxychloroquine 200 mg people who have issues with heart conditions, psoriasis, and diabetes should take consultation with a doctor in detail because this medicine may worsen their present medical condition as well. People with hypersensitivity to 4-aminoquinoline compounds should not get a prescription for Hydroxychloroquine 200mg. Children who weigh lesser than 31 kgs also should avoid taking Hydroxychloroquine 200mg.

What are The Medicines to Avoid While Treating with Hydroxychloroquine 200 mg?

Every medicine has certain functions to work inside the body after drug administration. Sometimes the existence of two or more medicines that target on same particular place can also lead to harm to the body. Also, some medicines do not interact with the body well in presence of other drugs working. So, side effects can occur as a result of it and we need to prevent that by learning about drug interactions of it. Hydroxychloroquine 200 mg might exhibit side effects if it interacts with other drugs like:

• Antacids
• Neostigmine
• Azithromycin
• Medications that alter liver functioning
• Aurothioglucose
• Medicines that extend QT interval
• Antiepileptics
• Cyclosporin
• Cimetidine
• Digoxin
• Pyridostigmine
• Insulin or anti-diabetic medicines
• Mefloquine
• Methotrexate

What are The Alternative Medicines for Hydroxychloroquine 200 mg?

Knowing alternative medicines of Hydroxychloroquine 200 mg comes in handy in case you cannot find this medicine on time from anywhere. Not only it will save your precious time of need but also make you aware of information that you can use in the future. So, here is a list of alternative medicine for Hydroxychloroquine 200mg that you can look into as follows:

• Methotrexate
• Enbrel (etanercept)
• Ivermectin

What is The Chemical Composition of Hydroxychloroquine 200 mg?

When it comes to knowing the chemical composition of Hydroxychloroquine 200 mg then the chemical formula of this medicine is C18H26ClN3O.

Frequently Asked Questions (FAQs)

Q. Can you use Hydroxychloroquine 200 mg as off-label prescription medicine?

For medical conditions like Dermatomyositis, cutaneous, Porphyria cutanea tarda, Primary Sjögren syndrome and also Sarcoidosis doctors suggest Hydroxychloroquine 200 mg as off-label prescription medicine.

Q. Why do I need eye check-ups now and then while taking hydroxychloroquine 200 mg?

Doctors frequently check up on your eyes because this medicine can affect parts of the body, especially the eyes.

Q. How effectively does Hydroxychloroquine 200 mg work against Malaria?

Hydroxychloroquine 200 mg is a medicine that treats Malaria but the best medicine to treat Malaria is still yet to be known. Yet, this medicine got recognition by World Health Organization as it also comes under their list of essential medicines.

Q. Hydroxychloroquine 200 mg comes under which category of drugs?

Primarily Hydroxychloroquine 200 mg comes under the drug class also known as aminoquinoline (antimalarial drug) and antirheumatic.

Q. Can consuming Hydroxychloroquine 200 mg affect breastfeeding women?

Hydroxychloroquine 200 mg transfers to breast milk as well, so there is no evidence or study to prove that this medicine cannot harm the baby or breastfeeding mother.

Q. What is the maximum dose of Hydroxychloroquine that doctors generally recommend for most medical treatments?

The maximum dose that doctors generally recommend of Hydroxychloroquine for most medical treatments is 400 mg.