CeleBREX 200mg Capsules

What is CeleBREX 200mg ?

CeleBREX 200mg is a nonsteroidal anti-inflammatory drugs (NSAIDs) used to relieve pain, inflammation & stiffness caused by osteoarthritis, rheumatoid arthritis & menstrual pain. It works by blocking the production of a certain chemical called cyclooxygenase (COX) involved in the production of prostaglandins. Prostaglandins are substances that are involved in causing pain, fever, and inflammation. By blocking the production of prostaglandins, CeleBREX reduces pain, inflammation, and fever.

CeleBREX 200mg is a COX-2 inhibitor used to relieve cyclooxygenase-2 liable for inflammation & pain associated with juvenile rheumatoid arthritis, painful menstruation & ankylosing spondylitis. It works by obstructing the action of the pain-inducing chemical messenger cyclo-oxygenase (COX) enzyme in the body involved in manufacturing certain chemical substances such as prostaglandins that source pain and swelling. The mode of administration of this drug is oral, and its effect occurs within one hour of intake. Celebrex 200mg may even be used to eliminate the risk of colorectal adenomas.

CeleBREX 200mg is a drug that is a very selective reversible inhibitor of the COX-2 isoform of cyclooxygenase. It works by inhibiting the conversion of arachidonic acid to prostaglandin precursors. CeleBREX 200mg exerts anti-inflammatory properties and analgesic properties. It is also known for its anti-cancer properties since it can impact genes and pathways involved in the inflammation and transformation of malignant tumors.

How does CeleBREX 200mg (Celecoxib) Capsule Work?

CeleBREX 200mg is the inhibitor of the COX-2 isoform of cyclooxygenase. Hence, it works by preventing the conversion of arachidonic acid to precursors of prostaglandins. CeleBREX 200 mg binds to a hydrophilic side pocket region close to the active COX-2 binding site with its polar sulfonamide side chain. This specific mode of action of CeleBREX 200 mg and its selectivity reduces inflammation and pain while restricting adverse effects on the gastrointestinal system.

After oral administration of 200mg twice daily, CeleBREX 200mg shows a dose-proportional rise in exposure with a more minor than the proportional increase at higher dosages. It is widely distributed and has a strong affinity for proteins. With a half-life of about 11 hours, it is CYP2C9 which is principally responsible for its metabolism.

Via enhanced reabsorption of the drug in Henle’s renal medullary thick ascending loop and maybe other distal nephron segments, inhibition of PGE2 production may result in salt and water retention. PGE2 appears to limit water reabsorption in the collecting ducts by blocking the effects of the antidiuretic hormone.

Also, this drug significantly impacts the genes and pathways involved in tumor inflammatory response and malignant transformation, not normal cells. Therefore, you can also use it to treat cancer.

The Chemical Structure and Composition of CeleBREX 200mg

The chemical name of CeleBREX 200mg, is 4-[5-(4-methyl phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide. CeleBREX 200mg is a pyrazole-substituted compound in the form of a white powder. It has a molecular weight of 381.38 and a formula of C17H14F3N3O2S, having inactive ingredients in the form of edible inks, gelatin, lactose monohydrate, magnesium stearate, povidone, croscarmellose sodium, and sodium lauryl sulfate.

What Type of Drugs Interact with CeleBREX 200mg ?

If you use an antidepressant, steroid medication, or medication to treat or prevent blood clots, you must visit your doctor before taking CeleBREX. The risk of developing a stomach ulcer or bleeding may arise if you combine certain medications with an NSAIDs).

CeleBREX 200mg can interact with many medications. It includes vitamins, herbal goods, prescriptions, and over-the-counter medicines. However, not all potential interactions are covered. You must inform your doctor about your medications and any new or discontinued ones.

There are a total of three-hundred and ninety drugs that interact with CeleBREX 200 mg. A few include aspirin, amlodipine, levothyroxine, lisinopril, oxycodone, and many more.

What are The Uses of CeleBREX 200mg (Celecoxib) Capsules ?

In terms of medical usage, a nonsteroidal anti-inflammatory medicine like CeleBREX 200mg, an anti-inflammatory drug (NSAID), functions by lowering hormones that lead to pain and inflammation in the body.

CeleBREX 200 mg is also used to treat pain or inflammation brought on by various illnesses, including menstruation discomfort, ankylosing spondylitis, and arthritis.

CeleBREX 200mg is also prescribed to young patients with juvenile rheumatoid arthritis who are at least two years old. It is applied to managing colon polyps that run in families.

CeleBREX 200 mg is a COX-2 inhibitor used to relieve inflammation & pain caused by juvenile rheumatoid arthritis, painful menstruation & ankylosing spondylitis. It is a nonsteroidal anti-inflammatory drug that contains CeleBREX 200 mg as an active ingredient works on cyclooxygenase-2, an enzyme that is liable for inflammation and pain associated with juvenile rheumatoid arthritis, painful menstruation, and ankylosing spondylitis.

What are The Dosage Guidelines for CeleBREX 200mg Capsule?

Creating a dosing schedule of CeleBREX 200mg depends on the type of medical condition and the individuals who can consume it. They are as follows:

Usual Adult Pain Dose:

Acute pain: 400 mg at first, then 200mg the next day if necessary. Followed by 200 mg twice daily after that, as required.

Typical adult dosage for dysmenorrhea:

400 mg at first, then 200mg the next day if necessary. 200 mg twice daily after that, as required.

osteoarthritis dosage for adults:

It is essential that you either consume 200mg once daily or 100 mg twice daily.

rheumatoid arthritis dosage for adults typically:

You must follow an oral dosage of 100–200 mg and be taken twice daily.

For Familial Adenomatous Polyposis, the typical adult dose:

You need to take the drug orally, twice daily, with food, 400 mg.

Adult Dose Customary for Ankylosing Spondylitis:

You either take 200mg once daily or 100 mg twice daily. A trial dose of 400 mg taken daily orally may be helpful if no improvements are seen after 6 weeks of medication. Consideration should be given to alternative treatment options if no progress has been seen after six weeks.

Standard pediatric dosage for rheumatoid arthritis in children:

For a child who is two years and over:

10 to 25 kg, but not more than that: 50 mg twice daily by mouth.

For a child weight with more than 25 kg: 100 mg can take orally twice daily.

What happens when you miss a dose of CeleBREX 200mg ?

Also, you must remember that if it is almost time for your next dose of CeleBREX 200mg, omit the missed dose and take the medication as soon as possible. Avoid combining two dosages and converting them into one.

On overdosing on CeleBREX 200mg, what needs to be done?

You must seek out immediate medical attention by calling on your doctor or contacting a medical helpline center.

What are The Side Effects of CeleBREX 200mg (Celecoxib) Capsules ?

If you experience a severe medication reaction that can damage many body parts, stop taking CeleBREX 200mg and get medical attention. Suppose you experience other side effects such as skin rash, fever, swollen glands, muscle aches, extreme weakness, unusual bruising, and yellowing of the skin or eyes, you need to visit your doctor immediately.

If you experience any of the following signs: heart attack or stroke, chest discomfort that spreads to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, swollen legs, or feeling out of breath. Other side effects include swelling in hands and feet, dizziness, or even cold symptoms such as sore throat and stuffy nose.

So, if you experience symptoms that include an allergic reaction to CeleBREX 200 mg (hives, difficulty breathing, swelling in your face or throat), or a severe skin reaction, get immediate emergency medical attention (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Adverse effects:

The side effects of CeleBREX 200mg, there are also a few adverse effects that you may have to look out for while using this drug. They are:

1.   Clear signs of cardiac problems
2.   Any form of a skin rash, which may be mild, moderate, or even severe
3.   Gastrointestinal bleeding symptoms include bloody or tarry stools, bloody coughing, or vomit that resembles coffee grounds;
4.   Nausea, upper right side stomach pain, itching, fatigue, dark urine, and jaundice (yellowing of the skin or eyes) are symptoms of liver disorders.
5.   Renal issues: inability to urinate frequently, ankle or foot edema, fatigue, or shortness of breath;
6.   Low red blood cell counts (anemia) are characterized by pale skin, unusual fatigue, dizziness or shortness of breath, and cold hands and feet.

The Precautions That You Need to Take While Consuming CeleBREX 200mg:

Frequent use of CeleBREX 200mg may result in deadly stomach or intestinal bleeding. Especially in elderly persons, these symptoms can develop while taking this medication. You should not use this medication if your stomach or intestines are already bleeding.

If you do not have any risk factors, CeleBREX 200 mg can increase your risk of a fatal heart attack or stroke. Consumption of CeleBREX before or right after heart bypass surgery is not advisable.

Use the lowest effective dose of CeleBREX 200 mg for the shortest time possible in NSAID-treated individuals to reduce the potential risk for a negative cardiovascular or CV event. Throughout the entire treatment period, even in the absence of prior CV symptoms, doctors and patients alike should be on the lookout for the emergence of such events. Patients should know the signs and symptoms of significant CV events and what to do in their case.

There is insufficient proof that taking aspirin simultaneously as an NSAID reduces the incidence of significant CV thrombotic events. Also, you must not use Aspirin and NSAIDs like CeleBREX 200mg together since it raises the risk of gastrointestinal (GI) problems.

What do You Need to Do Before Taking CeleBREX 200mg ?

CeleBREX 200mg is a medication you should not use if you:

1.   Have you had an NSAID or aspirin overdose in the past or a severe allergic reaction?
2.   Experienced Serious Bleeding issues or renal problems
3.   Struggled with a stomach ulcer, bleeding in the intestines or stomach
4.   Are you an alcoholic, heavy smoker, or an asthmatic

Above all, you should not take CeleBREX 200 mg while pregnant unless your doctor directs you. NSAID use in the final 20 weeks of pregnancy might result in significant heart or kidney problems for the unborn child. It could also lead to other complications in a pregnant woman.

How to Take CeleBREX 200mg ?

As directed by your doctor, you need to take CeleBREX 200mg . Ensure that you read all the drug guides and follow all instructions on your prescription label. The lowest dose that will effectively treat your illness you must use.

CeleBREX 200 mg you can take with or without food. If a capsule you cannot swallow in its whole form, you need to break it open and add the medication to a spoonful of applesauce. Using water, drink the concoction. This applesauce mixture can store up to 6 hours in the refrigerator for subsequent use.

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What are The Storage Instructions for CeleBREX 200mg Capsules?

Please ensure that you keep your CeleBREX 200mg drug at room temperature, away from heat and moisture. Also, store it away from children. The temperatures at which you need to keep this drug ranges from 20°C to 25°C (68°F to 77°F), with fluctuations within 15°C to 30°C (59°F to 86°F) permitted. Thus, you can store this medicatio to save it’s efficacy.

Frequently Asked Questions:

Q. Is CeleBREX 200mg an anti-inflammatory drug or a painkiller?

This medicine is a COX-2 inhibitor, a nonsteroidal anti-inflammatory drug (NSAID), which reduces pain and swelling (inflammation). So, you can use it as an anti-inflammatory drug or a painkiller to treat menstrual pain, acute pain and arthritis.

Q. Can CeleBREX 200mg have an impact on kidneys?

CeleBREX 200mg can sometimes cause kidney problems, such as acute kidney failure and kidney stones. In clinical studies of people who took this medication for OA or RA, acute kidney failure occurred in less than 0.1% of the group. And kidney stones occurred in 0.1% to 1.9% of the people.

Q. Is CeleBREX 200mg a muscle relaxant?

CeleBREX 200mg is a potent anti-inflammatory drug. So, it does not act as muscle relaxants or narcotics.

Q. How do you stop taking CeleBREX 200mg ?

Your symptoms may worsen if you abruptly stop taking CeleBREX. So, if your doctor does not instruct you to discontinue taking CeleBREX, do not. Your doctor could advise you to reduce the dose before breaking altogether gradually.

Q. Does CeleBREX 200mg cause blood clotting?

Compared to other NSAIDs, CeleBREX causes less stomach and intestinal inflammation and ulcers (at least with short-term usage) and does not prevent blood from clotting.