What is Aspadol 100mg?
Aspadol 100mg is an opioid analgesic (pain reliever) used to treat moderate to severe pain. It works by altering the pain sensation felt normally by the body by interacting with the neurotransmitters in the brain. Aspadol 100mg (Tapentadol) tab is a dual-acting synthetic analgesic to relieve acute & chronic pain. It works by exerting dual action mode with µ-opioid receptor & norepinephrine reuptake inhibitor. It inhibits the reuptake of noradrenaline (norepinephrine).
Aspadol 100mg (Tapentadol) tablet is prescribed in the form of immediate release (IR) & extended-release (ER) for the treatment of moderate to sever level of certain pain conditions. Immediate release (IR) Aspadol 100 mg tablet helps to treat acute pain (including pain after injury & surgery). Extended release Aspadol (ER) 100mg tablet is used as around the clock treatment for long acting pain like patients with chronic musculoskeletal pain & with diabetes when suffering from severe neuropathic pain (pain from nerve damage). ER tablets are released into your body slowly over the time.
History of Aspadol 100mg
By the end of the 1980s, Helmut Buschmann, in his pharmaceutical manufacturing company, Grunenthal, invented Tapentadol. The discovery came through microscopic analysis of the chemical structure and reactivity of an opioid analgesic called Tramadol. Coincidently, the invention of Tramadol and Tapentadol occurred in the same year, in 1962.
Reverse chemical engineering was done by understanding the chemical structure of Tramadol. Tramadol has several enantiomers, with each enantiomer metabolizing after its processing in the liver. These enantiomers act differently at a specific opioid receptor, the serotonin transporter, and the norepinephrine transporter.
Taking Tramadol as a pivot point, the scientists at Grunenthal found a single molecule with attributes such as minimizing the serotonin activity, having a strong specific opioid receptor agonist norepinephrine reuptake inhibition. On top of that, the newly found molecule was not a pro-drug. This unique molecule was later named as Tapentadol. It was approved by the US FDA in 2008 and further classified as a Schedule drug in 2009. Later in the year 2011, the FDA gave Tapentadol a green signal to treat neuropathic pain in diabetic patients.
How does Aspadol 100mg Tablet Work?
Tapentadol is a narcotic pain relieving medicine contains in Aspadol 100mg used as an opioid analgesic in the treatment of moderate to severe pain. Aspadol works to block the transmission of chemical messengers sending signal to the brain. Aspadol 100 mg helps by binding to opioid receptors in the brain and spinal cord, which helps to modulate pain signals. It also inhibits the reuptake of norepinephrine, a neurotransmitter involved in pain processing. Aspadol (Tapentadol) 100mg helps by activating the µ-opioid receptor & inhibiting the reuptake of norepinephrine in the brain. Aspadol 100mg is an agonist of the μ-opioid receptor & norepinephrine reuptake inhibitor. This results in an increase in the levels of extracellular norepinephrine, which in turn causes pain to subside.
Aspadol 100 mg tablet mainly imitates the impact of endorphins. It mixes the actions of endorphins with the opioid receptors in the brain and spinal cord. Aspadol works to block severe as well as mild pain receptors. It impacts directly on the central nervous system and convinces pain relief. It works on neurotransmitter that passes signals between nerve cells called norepinephrine in the brain. Norepinephrine is a chemical present in the body that performs as both a stress hormone and a neurotransmitter. The pain signals transferred
Also find more abut how Tapentadol 100mg treat moderate to severe pain?
What are The Uses of Aspadol 100mg Tablets?
Aspadol 100mg is used for the treatment of moderate to severe acute pain after surgery / injury & chronic pain conditions like neuropathic pain, musculoskeletal pain & cancer-related pain. It alters the manner in which the nervous system and brain perceive pain. It inhibits the reuptake of norepinephrine.
Aspadol 100mg (Tapentadol) is a pain relieving medicine used to heal moderate to severe pain in an acute conditions (by injury / surgery) & chronic pain (by neuropathy & musculoskeletal conditions) in adults. It works to block the transmission of pain signals between the nerves & spinal cord.
Aspadol ER 100mg is an around-the-clock opioid treatment indicated to treat long acting pain like neuropathy pain when around-the-clock opioid medication is required. Because, it is a long acting pain relieving medication.
What are The Dosage Guidelines of Aspadol 100mg Tablets ?
The dosage of Aspadol (Tapentadol) may vary depending on the individual’s medical condition, pain severity, and response to treatment. It is essential to follow your doctor’s prescribed dosage instructions. The typical recommended dosage for Aspadol is as follows:
- For adults: The initial dose is usually 50 to 100 mg every 4 to 6 hours as needed for pain relief. The maximum daily dose should not exceed 600 mg.
- For elderly patients (above 65 years): The initial dose is generally lower, usually 50 mg every 4 to 6 hours. The maximum daily dose has specific limit of upto 300 mg.
- For patients with moderate to severe renal impairment: The starting dose should be reduced to 50 mg every 8 to 12 hours. The maximum daily dose should not exceed 300 mg.
- For patients with moderate to severe hepatic impairment: The starting dose should be reduced to 50 mg every 8 to 12 hours. The maximum daily dose should not exceed 200 mg.
Please note that these are general guidelines, and your doctor may adjust the dosage based on your specific needs and medical condition.
Missed-Dosage Guidelines for Aspadol 100mg:
If you miss a dose of Aspadol 100mg (Tapentadol), it’s essential to follow certain guidelines:
Take it as soon as you remember:
If you realize you missed a dose and it is not close to the time of your next scheduled dose, take the missed dose as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Taking a double dose to make up for the missed one is not recommended.
Do not double dose:
Taking a double dose to compensate for a missed dose can increase the risk of side effects and overdose. Stick to your regular dosing schedule and avoid taking more than prescribed.
Follow doctor’s instructions:
Always adhere to your doctor’s prescribed dosing regimen for Aspadol 100mg. If you are unsure about what to do when you miss a dose, consult your healthcare provider for guidance.
Avoid catching up:
It can lead to an overdose or other health complications. So if you miss a dose, do not try to “catch up” by taking extra doses.
If you find it challenging to remember taking your medication regularly, consider setting alarms or reminders on your phone or using pill organizers to help you stay on track.
Do not abruptly stop or alter dosing:
If you frequently miss doses or are unable to follow the prescribed dosing schedule, speak with your doctor. They may need to adjust your treatment plan or suggest alternative pain management strategies.
Keep track of missed doses:
Maintain a record of your medication intake to identify any patterns of missed doses. This can help you and your doctor understand your adherence to the treatment plan better.
Speak with your doctor:
If you miss multiple doses or have difficulty sticking to the prescribed regimen, discuss this with your healthcare provider. They can provide guidance and support to ensure you get the most benefit from your medication.
Remember, Aspadol 100mg is a potent medication, and its effectiveness can be compromised if not taken as prescribed. Always prioritize communication with your healthcare provider to optimize pain management and minimize the risk of complications.
Over-Dosage Guidelines for Aspadol 100mg:
If someone has overdosed and is experiencing serious symptoms such as passing out or difficulty breathing, provide naloxone if it is available, and then contact 911. If the person is awake and showing no signs of poisoning, contact a poison control center immediately. Residents of the United States can contact their local poison control center by dialing 1-800-222-1222. Residents in Canada can seek assistance from their local poison control center. Overdose can be evident by the following symptoms: slow/shallow breathing, sluggish heartbeat, convulsions, and coma. Do not share the medication with anybody else. It is a violation of the law to disseminate it.
Do not share this drug with anybody else. It is against the law to distribute it.
Doctors prescribe this medication specifically to address your current condition. If your doctor suggests you this medication for one ailment, don’t use it for another unless your doctor tells you to. In that case, a requirement of different medication is possible.
Inquire with your doctor or pharmacist about whether you should keep naloxone on hand in case of an opioid overdose. Your family or household members should be aware of the instructions on how to spot and manage an opioid overdose.
How to Take Aspadol 100mg 100mg Tablets ?
Aspadol 100mg is classified as a Schedule II controlled substance in the United States due to its potential for abuse and dependence. So, use Aspadol 100mg tablets only as directed by a healthcare provider.
Here are the general guidelines on how to take Aspadol tablet:
- Follow the instructions provided by your doctor or pharmacist. Take the medication exactly as prescribed, including the dosage and duration of treatment.
- Swallow the tablet whole with a glass of water. Do not crush, break, or chew the tablet unless instructed otherwise by your healthcare provider.
- Aspadol can be taken with or without food. However, taking it with food may help reduce stomach upset.
- Do not exceed the recommended dose. Taking more than prescribed can increase the risk of side effects or overdose.
- If you forget to take a dose, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
- It is important to not suddenly stop taking Aspadol without consulting your doctor, as it may cause withdrawal symptoms. If you need to discontinue the medication, your doctor will provide guidance on how to gradually reduce the dose.
- Store Aspadol tablets in a cool, dry place away from direct sunlight. Keep them out of the reach of children and pets.
What are The Side Effects of Aspadol 100mg Tablets?
Aspadol 100mg, despite the fact that it is FDA-approved and safe to use, may cause some negative effects in a small number of people. Unless the symptoms persist or worsen, these side effects do not necessitate a visit to the doctor.
The adverse effects of Aspadol 100mg tablets are as below;
Aspadol 100mg has the following serious adverse effects;
If you encounter any of the above-mentioned side effects for an extended period of time, get medical treatment as soon as possible.
- Prior to receiving Aspadol 100mg, discuss with your doctor any past or present medical conditions or allergies that you may be suffering from.
- Opioids have the potential to become addictive. One can use Aspadol 100mg for a limited time, such as 2-3 weeks.
Stopping Aspadol 100mg should not be done hastily. It is less likely that you will have withdrawal symptoms if you discontinue gradually.
- Make sure to store the medication in an area that is clean, free of moisture, and dry. Please keep it out of direct sunlight if at all possible.
- Do not take Aspadol 100mg if you have taken any MAO inhibitors within the prior two weeks.
- Never self-medicate with a medicine that is only available by prescription, such as Aspadol 100mg.
- may become dizzy or drowsy if you consume alcohol or marijuana (cannabis). Do not drive, operate machinery, or do anything else that requires attentiveness unless you are confident that you can do so safely.
- Consume no alcoholic beverages. If you use marijuana, consult your doctor (cannabis)
- Inform your doctor or dentist about all of the products you consume before undergoing surgery.
Just follow the precautions given above & never fill pain with Aspadol 100mg pills.
Interactions between drugs might alter the way they operate or raise your chance of experiencing major adverse effects. This paper does not include all of the potential medication interactions that could occur. Keep a note of everything you use (including prescription and nonprescription drugs, herbal products, and vitamins) and share it with your doctor and pharmacist. Do not begin, stop, or modify the dosage of any medications without first obtaining your doctor’s permission.
Products such as some pain drugs (mixed opioid agonist-antagonists such as pentazocine, nalbuphine, and butorphanol), as well as naltrexone, have the potential to interact with this medication. Taking this medication in conjunction with MAO inhibitors may result in a significant (and perhaps fatal) drug interaction. If you are taking an MAO inhibitor (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, or tranylcypromine), you should avoid taking it while you are taking Aspadol 100mg. Avoid the majority of MAO inhibitors for at least two weeks prior to treatment with this prescription. Consult your doctor about the ideal time to start or stop using this medication.
If you are taking additional medications that elevate serotonin, you are at greater risk of developing serotonin syndrome/toxicity. Among other things, MDMA/”ecstasy,” St. John’s wort, and certain antidepressants (including SSRIs such as fluoxetine/paroxetine, and SNRIs such as duloxetine/venlafaxine) are examples of substances that are considered to be addictive. When you first begin taking these medications or when you raise the dose, you may be more susceptible to serotonin syndrome/toxicity.
This drug has the potential to interact with certain laboratory tests (amylase/lipase levels), resulting in erroneous test findings in some cases. Make certain that all laboratory employees and all of your doctors are aware that you are taking this medication.
It is important to read the labels on all of your medications (including allergy and cough-and-cold remedies). Because, they may contain substances that induce drowsiness. Inquire with your pharmacist about the proper way to use those products.
If you use this medication with other medications that can cause drowsiness or breathing problems, the risk of serious side effects (such as slow/shallow breathing and severe drowsiness/dizziness) can increase. If you are taking any other medications, such as other opioid pain relievers or cough suppressants (such as codeine or hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, or zolpidem), muscle relaxants (such as carisoprodol or cyclobenzaprine), or antihistamines, tell your doctor or pharmacist before taking Aspadol 100mg (such as cetirizine, diphenhydramine).
Alternate Brands for Aspadol 100mg
There are some alternatives for moderate to sever pain & musculoskeletal pain given as below;
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How to Store Aspadol 100mg Tablets?
Store Aspadol 100mg at room temperature, away from direct sunlight and water vapor. Do not store this medication in the bathroom as per the doctor’s recomendations. Keep the drug out of the reach of children and pets at all times. Unless specifically ordered to do so, do not flush drugs down the toilet or pour them down the drain. When this product is no longer in use dispose it of properly. Thus, you can store Aspadol 100mg.
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Q. What is Aspadol 100mg used for?
Aspadol 100mg is used to relieve moderate to severe pain, such as pain from injuries, surgeries, or chronic conditions.
Q. What to do in case you forget to take a dose of Aspadol 100mg?
If you forget to take a dose, make sure to take it as soon as you remember. Unless it is close to the time of the next dose, do not take the missed dose. Make sure you take your next dose at the scheduled time. Do not increase the dose to make up for a lost time.
Q. Does Aspadol 100mg really work?
Aspadol 100mg tab is a narcotic pain relieving tablet contains Tapentadol that acts as an analgesic in the treatment of moderate to severe acute pain (pain that begins suddenly, has a specific cause, and the one which goes away when the cause of the pain heals). It works by binding to specific receptors in the brain and spinal cord that are involved in the transmission of pain signals
Q. Can a nursing woman take Aspadol 100 mg?
It is uncertain whether this medicine is excreted in breast milk. It could have a negative impact on a nursing infant. So, Inform your doctor straight away if your infant develops unusual lethargy, difficulty eating, or breathing difficulties. Before you start breastfeeding, talk to your doctor.
Q. How long does it take for Aspadol 100mg to start working?
When taking Aspadol 100mg, the absorption of the medication takes at least 30 minutes into the bloodstream and starts working as an analgesic ( relief from pain). Its effects can last anywhere between 4 and 6 hours. Also, Aspadol (Tapentadol) tab is a long acting pain relieving medicine used for around-the-clock pain treatment.
Q. Can Aspadol 100mg be addictive?
Yes, Aspadol 100mg contains tapentadol, which is an opioid, and it can lead to physical and psychological dependence if misused or taken for extended periods. So, take it only as per the prescription.
Q. Is Aspadol 100mg suitable for older adults?
Elderly patients may require lower doses of Aspadol 100mg due to age-related changes in drug metabolism. Consult a healthcare professional for appropriate dosing.
Q. Can I drink alcohol while taking Aspadol 100mg?
Combining alcohol with Aspadol 100mg can enhance the sedative effects and increase the risk of dangerous side effects. It’s best to avoid alcohol while using this medication.
Q. Can Aspadol 100mg be used during pregnancy?
Aspadol 100mg is not recommended during pregnancy, as it may harm the unborn baby. Consult a healthcare professional for safer pain management options during pregnancy.
Q. Can Aspadol 100mg be taken with other medications?
Aspadol 100mg may interact with other drugs, including antidepressants, sedatives, and other opioids. Inform your healthcare provider about all medications you are taking to avoid potential interactions. Thus, you can take this medication with other medicines only after the consultation.
Q. Can Aspadol 100mg be crushed or split?
Aspadol 100mg tablets should be taken whole and should not be crushed, chewed, or split, as doing so may alter the drug’s release mechanism.
Q. Can Aspadol 100mg be taken with grapefruit or grapefruit juice?
Grapefruit and grapefruit juice may interact with Aspadol 100mg, affecting how the body metabolizes the drug. It’s best to avoid grapefruit products while using this medication.
Q. Is Aspadol 100mg available over-the-counter?
No, Aspadol 100mg is a prescription medication and requires a doctor’s prescription to obtain it. So, it is not available over the counter.
Q. Can Aspadol 100mg be used to treat pain in children?
Aspadol 100mg is not typically recommended for use in children. So, do not use this medicine for children. Alternative pain management options should be explored for pediatric patients.
Q. Aspadol vs Nucynta : Which Is Better?
In order to provide consumers with the chemical ingredient Tapentadol, which is responsible for the relief of pain, in the markets Aspadol is the brand name. To the general public, Aspadol is seen under the brand name Tapentadol. Where as Nucynta’s chemical ingredient is Tapentadol also works to relieve pain. Aspadol / Nucynta, arriving from the drug Tapentadol. Nucynta 100 mg or Aspadol 100mg is a generic name of Tapentadol 100 mg. Aspadol 100 mg produces outcomes that are comparable to Nucynta, also its efficacy is on par with that of its competitors. Thus, Aspadol & Nucynta are the same medication.