Probenecid is a medication used to treat gout, a type of arthritis caused by the buildup of uric acid crystals in the joints. It works by reducing the amount of uric acid in the blood, which can help prevent the formation of uric acid crystals in the joints.
Probenecid does this by blocking the reabsorption of uric acid in the kidneys, which increases the amount of uric acid that is excreted in the urine. This can help lower the level of uric acid in the blood and reduce the risk of gout attacks.
Probenecid is available in tablet form and is usually taken two to four times a day, depending on the individual’s response to the medication. It is often used in combination with other medications for gout, such as colchicine or nonsteroidal anti-inflammatory drugs (NSAIDs).
While probenecid is generally considered safe and effective, it can have side effects such as nausea, vomiting, headache, and rash. Rarely, probenecid can cause more serious side effects such as kidney stones or a decrease in white blood cell count. Patients taking probenecid should be closely monitored by their healthcare provider and report any unusual symptoms or side effects. Additionally, probenecid can interact with other medications, so patients should inform their healthcare provider of all medications they are taking before starting probenecid.