What is Necrolysis ?

Toxic epidermal necrolysis (TEN) is a rare but serious skin condition that results in the separation and death of the top layer of skin (epidermis) from the underlying skin layers. It is also referred to as “necrolysis” or “Lyell syndrome.”

TEN is considered a severe form of erythema multiforme, a skin condition that causes red, raised patches or blistering on the skin. TEN can be caused by a reaction to certain medications, including antibiotics, anti-seizure medications, and painkillers.

The symptoms of TEN can include fever, headache, and flu-like symptoms, followed by the sudden onset of skin rashes and blisters, which can quickly spread to cover a large portion of the body. The condition can be very painful, and in severe cases, it can lead to life-threatening complications such as dehydration, infection, and organ failure.

Treatment for TEN typically involves stopping the use of the medication that is causing the reaction, as well as supportive care to manage the symptoms, such as fluid and electrolyte replacement, wound care, and pain management.

It is important to seek medical attention immediately if you have symptoms of TEN, as the condition can progress rapidly and can be life-threatening.

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